欧文論文
２０２３
Furuya T, Ishihara S, Ogi H, Masuda K, Shibata S, Nakazono C, Okada S, Shimomura M, Tando S, Yaoi T, Maeda Y, Yamagishi M, Kawamoto H, Itoh K, Inoue M. Characteristic differences in the abundance of tumor-infiltrating lymphocytes and intratumoral developing T cells in thymoma, with special reference to PD-1 expression. Cancer Immunol Immunother. doi:10.1007/s00262-023-03431-5
２０２２
Nagahata Y, Masuda K, Nishimura Y, Ikawa T, Kawaoka S, Kitawaki T, Nannya Y, Ogawa S, Suga H, Satou Y, Takaori-Kondo A, Kawamoto H. Tracing the evolutionary history of blood cells to the unicellular ancestor of animals. Blood. 140(24):2611-2625. 2022 doi:10.1182/blood.2022016286
Tanaka A, Nakano TA, Nomura M, Yamazaki H, Bewersdorf JP, Mulet-Lazaro R, Hogg H, Liu B, Penson A, Yokoyama A, Zang W, Havermans M, Koizumi M, Hayashi Y, Cho H, Kanai A, Lee SC, Xiao M, Koike Y, Zhang Y, Fukumoto M, Aoyama Y, Konuma T, Kunimoto H, Inaba T, Nakajima H, Honda H, Kawamoto H, Delwel R, Abdel-Wahab O, Inoue D. Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia. Blood. 140(8):875-888. 2022 doi:10.1182/blood.2021015325
Mizuno R, Hojo H, Takahashi M, Kashio S, Enya S, Nakao M, Konishi R, Yoda M, Harata A, Hamanishi J, Kawamoto H, Mandai M, Suzuki Y, Miura M, Bamba T, Izumi Y, Kawaoka S. Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase. Nat Commun. 13(1):3346. 2022 doi:10.1038/s41467-022-30926-z.
Kato K, Inoue E, Tanaka S, Kawamoto H. Increase in the incidence of acute inflammatory reactions to injectable fillers during COVID-19 era. J Cosmet Dermatol. 21(5):1816-1821. 2022 doi:https://doi.org/10.1111/jocd.14886
２０２１
Terada K, Kondo K, Ishigaki H, Nagashima A, Satooka H, Nagano S, Masuda K, Kawamura T, Hirata T, Ogasawara K, Itoh Y, Kawamoto H, Agata Y. Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model. Mol Ther Oncolytics. 24:77-86. 2021 doi:https://doi.org/10.1016/j.omto.2021.12.003
２０２０
Maeda T, Nagano S, Kashima S, Terada K, Agata Y, Ichise H, Ohtaka M, Nakanishi M, Fujiki F, Sugiyama H, Kitawaki T, Kadowaki N, Takaori-Kondo A, Masuda K, Kawamoto H. Regeneration of tumor antigen-specific cytotoxic T lymphocytes from iPSCs transduced with exogenous TCR genes. Mol Ther Methods Clin Dev. 19:250-260. 2020 doi:10.1016/j.omtm.2020.09.011.
Kashima S, Maeda T, Masuda K, Nagano S, Inoue T, Takeda M, Kono Y, Kobayashi T, Saito S, Higuchi T, Ichise H, Kobayashi Y, Iwaisako K, Terada K, Agata Y, Numakura K, Saito M, Narita S, Yasukawa M, Ogawa O, Habuchi T, Kawamoto H. Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model. iScience. 23(4):100998. 2020 doi:10.1016/j.isci.2020.100998.
２０１９
Nagano S, Maeda T, Ichise H, Kashima S, Ohtaka M, Nakanishi M, Kitawaki T, Kadowaki N, Takaori-Kondo A, Masuda K, Kawamoto H. High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells. Mol Ther Methods Clin Dev. 16:126-135. 2019 doi:10.1016/j.omtm.2019.12.006.
Good ML, Raul Vizcardo R, Maeda T, Tamaoki N, Malekzadeh P, Kawamoto H. Restifo NP. Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-Specific T Cells. J Vis Exp. (152). 2019 doi:10.3791/59997.
Hojo MA, Masuda K, Hojo H, Nagahata Y, Yasuda K, Ohara D, Takeuchi Y, Hirota K, Suzuki Y, Kawamoto H, Kawaoka S. Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection. Nat Commun. 10(1):2603. 2019 doi:10.1038/s41467-019-10525-1.
Gong B, Kiyotani K, Sakata S, Nagano S, Kumehara S, Baba S, Besse B, Yanagitani N, Friboulet L, Nishio M, Takeuchi K, Kawamoto H, Fujita N, Katayama R. Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer. J Exp Med. 216(4): 982-1000. 2019 doi:10.1084/jem.20180870.
２０１８
Miyai T, Takano J, Endo TA, Kawakami E, Agata Y, Motomura Y, Kubo M, Kashima Y, Suzuki Y, Kawamoto H, Ikawa T. Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells. Genes Dev. 15;32(2):112-126. 2018 doi:10.1101/gad.309575.117.
Tenno M, Kojo S, Lawir DF, Hess I, Shiroguchi K, Ebihara T, Endo TA, Muroi S, Satoh R, Kawamoto H, Boehm T, Taniuchi I. Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors. J Exp Med. 215:595-610. 2018 doi:10.1084/jem.20171221.
２０１７
Ichise H, Nagano S, Maeda T, Miyazaki M, Miyazaki Y, Kojima H, Yawata N, Yawata M, Tanaka H, Saji H, Masuda K, and Kawamoto H. NK cell alloreactivity against KIR ligand-mismatched HLA-haploidentical tissue derived from HLA haplotype-homozygous iPS cells. Stem Cell Reports. 9:853-867. 2017 doi:10.1016/j.stemcr.2017.07.020.
Seki M, Kimura S, Isobe T, Yoshida K, Ueno H, Nakajima-Takagi Y, Wang C, Lin L, Kon A, Suzuki H, Shiozawa Y, Kataoka K, Fujii Y, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Masuda K, Kawamoto H, Ohki K, Kato M, Arakawa Y, Koh K, Hanada R, Moritake H, Akiyama M, Kobayashi R, Deguchi T, Hashii Y, Imamura T, Sato A, Kiyokawa N, Oka A, Hayashi Y, Takagi M, Manabe A, Ohara A, Horibe K, Sanada M, Iwama A, Mano H, Miyano S, Ogawa S, Takita J. Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia. Nat Genet. 49:1274-1281. 2017 doi:10.1038/ng.3900.
Noguchi S, (Kawamoto H; 78th of 178 authors) FANTOM5 CAGE profiles of human and mouse samples. Sci Data. 4:170112.2017 doi:10.1038/sdata.2017.112.
Miyazaki M, Miyazaki K, Chen K, Jin Y, Turner J, Moore AJ, Saito R, Yoshida K, Ogawa S, Rodewald HR, Lin YC, Kawamoto H, Murre C. The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development. Immunity. 46(5):818-834.e4. 2017 doi:10.1016/j.immuni.2017.04.022.
２０１６
Maeda T, Nagano S, Ichise H, Kataoka K, Yamada D, Ogawa S, Koseki H, Kitawaki T, Kadowaki N, Takaori-Kondo A, Masuda K, Kawamoto H. Regeneration of CD8αβ T cells from T cell-derived iPSC imparts potent tumor antigen-specific cytotoxicity. Cancer Res. 76(23):6839-6850. 2016 doi:10.1158/0008-5472.CAN-16-1149
Ikawa T, MasudaK, Endo TA, Endo M, Isono K, Koseki Y, Nakagawa R, Kometani K, Takano J, Agata Y, Katsura Y, Kurosaki T, Vidal M, Koseki H, Kawamoto H. Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of B lineage program. Genes Dev. 30(22):2475-2485. 2016 doi:10.1101/gad.290593.116
Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, Yanagita M. Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI insight. 1(11): e87680. 2016 doi:10.1172/jci.insight.87680.
Masuda J, Kawamoto H, Strober W, Takayama E, Mizutani A, Murakami H, Ikawa T, Kitani A, Maeno N, Shigehiro T, Satoh A, Seno A, Arun V, Kasai T, Fuss IJ, Katsura Y, Seno M. Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting. Appl Biochem Biotechnol. pp1-15. 2016 doi:10.1007/s12010-016-2187-4
Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazaki Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S. Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers. Nature. 534:402-406. 2016 doi:10.1038/nature18294.
Satoh R, Kakugawa K, Yasuda T, Yoshida H, Sibilia M, Katsura Y, Levi B, Abramson J, Koseki Y, Koseki H, van Ewijk W, Hollander GA, Kawamoto H. Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells. PLoS Genet. 20;12(1):e1005776. 2016 doi:10.1371/journal.pgen.1005776.
２０１５
Ikawa T, Masuda K, Huijskens MJ, Satoh R, Kakugawa K, Agata Y, Miyai T, Germeraad WT, Katsura Y, and Kawamoto H. Induced developmental arrest of early hematopoietic progenitors leads to the generation of leukocyte stem cells. Stem Cell Reports. 5: 716-727. 2015 doi:10.1016/j.stemcr.2015.09.012.
Inoue T, Morita M, Hijikata A, Fukuda-Yuzawa Y, Adachi S, Isono K, Ikawa T, Kawamoto H, Koseki H, Natsume T, Fukao T, Ohara O, Yamamoto T, Kurosaki T. CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability. J Exp Med. 212: 1465-79. 2015 doi:10.1084/jem.20150384.
Iguchi T, Aoki K, Ikawa T, Taoka M, Taya C, Yoshitani H, Toma-Hirano M, Koiwai O, Isobe T, Kawamoto H, Masai H, Miyatake S. BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells. J Immunol. 195: 982-93. 2015 doi: 10.4049/jimmunol.1500602.
Arner E et al（Kawamoto H: The 38th in 109 auhtors）. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science. 347(6225): 1010-1014, 2015 doi:10.1126/science.1259418.
Miyazaki M, Miyazaki K, Chen S, Chandra V, Wagatsuma K, Agata Y, Rodewald HR, Saito R, Chang AN, Varki N, Kawamoto H, Murre C. The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis. Genes Dev. 29: 409-425. 2015 doi:10.1101/gad.255331.114.
２０１４
Stinke FC, Yu S, Zhou X, Yang W, Zhou B, Kawamoto H, Zhu J, Tan K, Xue HH. TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells. Nat Immunol. 15: 646-656. 2014 doi:10.1038/ni.2897.
Hoshii T1, Kasada A, Hatakeyama T, Ohtani M, Tadokoro Y, Naka K, Ikenoue T, Ikawa T, Kawamoto H, Fehling HJ, Araki K, Yamamura K, Matsuda S, Hirao A. Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells. Proc Natl Acad Sci USA. 11;111(10):3805-3810. 2014 doi:10.1073/pnas.1320265111.
２０１３
Okuyama K, Ikawa T, Gentner B, Hozumi K, Harnprasopwat R, Lu J, Yamashita R, Ha D, Toyoshima T, Chanda B, Kawamata T, Yokoyama K, Wang S, Ando K, Lodish HF, Tojo A, Kawamoto H, Kotani A. MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors. Proc Natl Acad Sci USA. 110: 13410-13415. 2013 doi:10.1073/pnas.1220710110.
Katagiri T*, Kawamoto H*, Nakakuki T*, Ishiyama K, Okada-Hatakeyama Ohtake S, Seiki S, Hosokawa K and Shinji Nakao. (*equal contribution) Individual hematopoietic stem cells in human bone marrow of patients with aplastic anemia or myelodysplastic syndrome stably give rise to limited cell lineages. Stem Cells. 31(3): 536-546. 2013 doi:10.1002/stem.1301.
Vizcardo R, Masuda K, Yamada D, Ikawa T, Shimizu K, Fujii S-I, Koseki H, Kawamoto H. Regeneration of human tumor antigen-specific T cells from iPS cells derived from mature CD8+ T cells. Cell Stem Cell. 12(1): 31-36. 2013 doi:10.1016/j.stem.2012.12.006.
２０１２
Isoda T, Takagi M, Piao J, Nakagama S, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S. Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM. Blood. 120(4): 789-799. 2012 doi:10.1182/blood-2012-02-413195.
Seo W, Ikawa T, Kawamoto H, Taniuchi I. Runx1-Cbfβ facilitates early B lymphocyte development by regulating expression of Ebf1. J Exp Med. 209(7): 1255-1262. 2012 doi:10.1084/jem.20112745
Watarai H, Sekine-Kondo E, Shigeura T, Motomura Y, Yasuda T, Satoh R, Yoshida H, Kubo M, Kawamoto H, Koseki H, Taniguchi M. Development and function of invariant natural killer T cells producing t(h)2- and t(h)17-cytokines. PLOS Biology. 10: e1001255. 2012 doi:10.1371/journal.pbio.1001255.
２０１１
Shibata K, Yamada H, Sato T, Dejima T, Nakamura M, Ikawa T, Hara H, Yamasaki S, Kageyama R, Iwakura Y, Kawamoto H, Toh H, Yoshikai Y. Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells. Blood. 118(3):586-593. 2011 doi:10.1182/blood-2011-02-334995.
Guo Y, Miyazaki M, Itoi M, Satoh R, Iwama A, Amagai T, Kawamoto H, Kanno M. Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells. Eur J Immunol. 41(4):1098-1107. 2011 doi:10.1002/eji.201040794.
２０１０
Miyazaki K, Miyazaki M, Guo Y, Yamasaki N, Kanno M, Honda Z, Oda H, Kawamoto H, Honda H. The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells. J Immunol.185(12):7330-7339. 2010 doi:10.4049/jimmunol.1001381.
Ikawa, T, S Hirose, K Masuda, K Kakugawa, R Satoh, A Shibano-Satoh, R Kominami, Y Katsura, H Kawamoto. An essential developmental checkpoint for production of the T cell lineage. Science. 329(5987): 93-96. 2010 doi:10.1126/science.1188995.
Hirose K, T Inukai, J Kikuchi, Y Furukawa, T Ikawa, H Kawamoto, S H Oram, B Göttgens, N Kiyokawa, Y Miyagawa, H Okita, KAkahane, X Zhang, I Kuroda, H Honna, K Kagami, K Goi, Hu Kurosawa, A T Look, H Matsui, T Inaba, Kanji Sugita. Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). Blood. 116(6):962-970. 2010 doi:10.1182/blood-2009-09-244673.
Y. Nishikawa, F. Hirota, M. Yano,H. Kitajima, J.Miyazaki, H. Kawamoto, Y. Mouri,and M. Matsumoto. Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation. J Exp Med. 207(5):963-971. 2010 doi:10.1084/jem.20092144.
Oguro H, Y Jin, H Ichikawa, T Ikawa, S Yamazaki, H Kawamoto, H Nakauchi, A Iwama. Poised lineage specification in multipotent hematopoietic progenitor cells by the polycomb protein Bmi1. Cell Stem Cell. 6(3): 279-286. 2010 doi:10.1016/j.stem.2010.01.005.
Moro K., T. Yamada, M. Tanabe, T. Takeuchi, T. Ikawa, H. Kawamoto, J-I. Furusawa, M. Ohtani, H. Fujii, and S. Koyasu. Innate production of Th2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphocytes. Nature. 463(7280): 540-544. 2010 doi:10.1038/nature08636.
Meek B, S Cloosen, C Borsotti, J Van Elssen, J Vanderlocht, M Schnijderberg, M van der Poel, B Leewis, R Hesselink, M G Manz, Y Katsura, H Kawamoto, W TV Germeraad and G MJ Bos. In vitro-differentiated T/natural killer-cell progenitors derived from human CD34+ cells mature in the thymus. Blood. 115(2):261-264. 2010 doi:10.1182/blood-2009-05-223990.
Watarai H, A Rybouchkin, N Hongo, Y Nagata, S Sakata, E Sekine, N Dashtsoodol, T Tashiro, S-I Fujii, K Shimizu, K Mori, K. Masuda, H Kawamoto, H Koseki, and M Taniguchi. Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Vα14-Jα18 TCRα gene. Blood. 115(2):230-237. 2010 doi:10.1182/blood-2009-04-217729.
Vroegindeweij, E., S Crobach, M Itoic, R Satoh, S Zuklys, C Happee, W TV Germeraad, J J Cornelissen, T Cupedo, G A Hollander, H Kawamoto, and W van Ewijk. Thymic cysts originate from Foxn1 positive thymic medullary epithelium. Mol Immunol. 47(5): 1106-1113. 2010 doi:10.1016/j.molimm.2009.10.034.
２００９
Imada M, Masuda K, Satoh R, Ito Y, Goto Y, Matsuoka T, Endo S, Nakamura A, Kawamoto H, Takai T. Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses. Int Immunol. 21(10):1151-1161. 2009 doi:10.1093/intimm/dxp081.
Kakugawa K., T. Yasuda, I. Miura, A. Kobayashi, H. Fukiage, R. Satoh, M. Matsuda, H. Koseki, S. Wakana, H. Kawamoto*, H. Yoshida*. (*correspondence) A novel gene essential for the development of single positive thymocytes. Mol Cell Biol. 29(18):5128-5135. 2009 doi:10.1128/MCB.00793-09.
Higashi, A. Y., T. Ikawa, M. Muramatsu, A. N. Economides, A. Niwa, T. Okuda, A. J. Murphy, J. Rojas, T. Heike, T. Nakahata,H. Kawamoto, T. Kita, and Motoko Yanagita. Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2. J Immunol. 182(9):5633-5640. 2009 doi:10.4049/jimmunol.0802413.
K. Masuda, W. T.V. Germeraad, R. Satoh, M. Itoi, T. Ikawa, N. Minato, Y. Katsura, W. van Ewijk, and H. Kawamoto. Notch activation in thymic epithelial cells induces development of thymic microenvironments. Mol Immunol. 46(8-9):1756-1767. 2009 doi:10.1016/j.molimm.2009.01.015.
Komaniwa S, H Hayashi, H Kawamoto, T. Ikawa, Satoshi B. Sato, Y Katsura, K Udaka. Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage. Eur J Immunol. 39(1):96-122. 2009 doi:10.1002/eji.200838796.
２００８
Yano M, Kuroda N, Han H, Horike M, Nishikawa Y, Kiyonari H, Maemura K, Yanagawa Y, Obata K, Takahashi S, Ikawa T, Satoh R, Kawamoto H, Muroi Y, and Matsumoto M. Aire controls the differentiation of thymicepithelial cells in the medulla for the establishment of self-tolerance. J Exp Med. 205(12): 2827-2838. 2008 doi:10.1084/jem.20080046.
Muroi, S., Y Naoe, C Miyamoto, K Akiyama, T Ikawa, K Masuda, H Kawamoto and I Taniuchi. Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol. 9(10):1113-1121. 2008 doi:10.1038/ni.1650.
Ko J., N Patel, T Ikawa, H Kawamoto, O Frank, R Rivera, RA van Etten and C Murre. Suppression of E-protein activity interferes with the development of BCR-ABL-mediated myeloproliferative disease. PNAS. 105(35):12967-12972. 2008 doi:10.1073/pnas.0805073105
Wada H, Masuda K, Satoh R, Kakugawa K, Ikawa, T, Katsura Y, Kawamoto H. Adult T cell progenitors retain myeloid potential. Nature. 452(7188): 768-772. 2008 doi:10.1038/nature06839.
Miyazaki M, Miyazaki K, Itoi M, Katoh Y, Guo Y, Kanno R, Katoh-Fukui Y, Honda H, Amagai T, van Lohuizen M, Kawamoto H and Kanno M. Thymocyte proliferation induced by pre-T cell receptor signaling is maintained through polycomb gene product Bmi-1-mediated Cdkn2a repression. Immunity. 28(2): 231-245. 2008 doi:10.1016/j.immuni.2007.12.013.
Xing Y, Wang X, Igarashi H, Kawamoto H, Sakaguchi N. Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes. Mol Immunol. 45(7): 2028-2037. 2008 doi:10.1016/j.molimm.2007.10.028
Kato M, Masuda K, Kakugawa K, Kawamoto H, Mugishima H, Katsura Y Quantification of progenitors capable of generating T cells in human cord blood. Eur J Haematol. 80(2):151-159. 2008 doi:10.1111/j.1600-0609.2007.00991.x
２００７
Agata Y, Tamaki N, Sakamoto S, Ikawa T, Masuda K, Kawamoto H, Murre C. Regulation of T cell receptor Beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. Immunity. 27(6):871-884. 2007 doi:10.1016/j.immuni.2007.11.015
Wakao H, Kawamoto H, Sakata S, Inoue K, Ogura A, Wakao R, Oda A, Fujita H. A novel mouse model for invariant NKT cell study. J Immunol. 179(6):3888-3895. 2007 doi:10.4049/jimmunol.179.6.3888
Hijikata A et al. (Kawamoto H;12th of 40 authors) Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics. 23(21):2934-2941. 2007 doi:10.1093/bioinformatics/btm430
Masuda K, Kakugawa K, Nakayama T, Minato M, Katsura Y, Kawamoto H. T cell lineage determination precedes the initiation of TCR gene rearrangement. J Immunol. 179(6): 3699-3706. 2007 doi:10.4049/jimmunol.179.6.3699
２００６
Nijhof, J. G., Braun, K. M., Giangreco, A., van Pelt, C., Kawamoto, H., Boyd, R. L., Willemze, R., Mullenders, L. H., Watt, F. M., de Gruijl, F. R. and van Ewijk, W. The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells. Development. 133(15): 3027-3037. 2006 doi:10.1242/dev.02443
Motohara, M.; Ibuki, K.; Miyake, A.; Fukazawa, Y.; Inaba, K.; Suzuki, H.; Masuda, K.; Minato, N.; Kawamoto, H.; Nakasone, T.; Honda, M.; Hayami, M.; Miura, T. Impaired T-cell differentiation in the thymus at the early stages of acute pathogenic chimeric simian-human immunodeficiency virus (SHIV) infection in contrast to less pathogenic SHIV infection. Microbes Infect. 8(6):1539-1549. 2006 doi:10.1016/j.micinf.2006.01.011
Ikawa, T., H. Kawamoto, A.W. Golodrath. And C. Murre. E protein and Notch signaling cooperate to promote T cell lineage specification and commitment. J Exp Med. 203(5):1329-1342. 2006 doi:10.1084/jem.20060268
２００５
Masuda, K., H. Kubagawa, T. Ikawa, C. C. Chen, K. Kakugawa, M. Hattori, R. Kageyama, M. D. Cooper, N. Minato, Y. Katsura, and H. Kawamoto. Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors. EMBO J. 24(23):4052-4060. 2005 doi:10.1038/sj.emboj.7600878
Lu, M., R. Tayu, T. Ikawa, K. Masuda, I. Matsumoto, H.Mugishima, H. Kawamoto, and Y. Katsura. 2005. The earliest thymic progenitors in adults are restricted to T, NK and dendritic cell lineages and have a potential to form more diverse TCR-b chains than fetal progenitors. J Immunol. 175(9): 5848-5856. 2005 doi:10.4049/jimmunol.175.9.5848
Suzuki, H. Motohara, M. Miyake, A. Ibuki, K. Fukazawa, Y. Inaba, K. Masuda, K. Minato, N. Kawamoto, H. Hayami, M. Miura, T. Intrathymic effect of acute pathogenic SHIV infection on T-lineage cells in newborn macaques.Microbiol Immunol. 49(7): 667-679. 2005 doi:10.1111/j.1348-0421.2005.tb03646.x
Masuda, K., Itoi, M., Amagai, T., Minato, N., Katsura, Y., Kawamoto, H. Thymic anlage is colonized by progenitors restricted to T, NK and dendritic cell lineages. J Immunol. 174(5): 2525-2532. 2005 doi:10.4049/jimmunol.174.5.2525
Miyazaki, M., Kawamoto, H., Kato, Y., Itoi, M., Miyazaki, K., Masuda, K., Tashiro, S., Ishihara, H., Igarashi, K., Amagai, T., Kanno, R., and Kanno, M. Polycomb Group Gene mel-18 Regulates Early T Progenitor Expansion by Maintaining the Expression of Hes-1, a Target of the Notch Pathway. J Immunol. 174(5): 2507-2516. 2005 doi:10.4049/jimmunol.174.5.2507
２００４
Li, Y., T. Koshiba, A. Yoshizawa, Y. Yonekawa, K. Masuda, A. Ito, M. Ueda,T. Mori, H. Kawamoto, Y. Tanaka, S. Sakaguchi, N. Minato, K. J. Wood, and K. Tanaka. Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. Am J Transplant. 4(12):2118-2125. 2004 doi:10.1111/j.1600-6143.2004.00611.x
Ikawa, T., Kawamoto, H., Wright L.Y. T., Murre, C. Long term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity. 20(3): 349-360. 2004 doi:10.1016/s1074-7613(04)00049-4
Ikawa, T, Masuda, K., Lu, M., Minato, N., Katsura, Y., Kawamoto, H. Identification of the earliest prethymic T cell progenitors in murine fetal blood. Blood. 103(2): 530-537. 2004 doi:10.1182/blood-2003-06-1797
２００３
Germeraad, W.T.V., Kawamoto, H., Itoi, M. Jiang, Y-F., Amagai, T., Katsura, Y., and van Ewijk, W. Development of thymic microenvironment in vitro is oxgen-dependent and requires permanent presence of T cell progenitors. J Histochem Cytochem. 51(9):1225-1235. 2003 doi:10.1177/002215540305100913
Shen, H.Q., Lu, M., Ikawa, T., Masuda, K., Ohmura, K., Minato, N., Katsura, Y., and Kawamoto, H. T/NK bipotent progenitors in the thymus retain the potential to generate dendritic cells. J Immunol. 171(7): 3401-3406. 2003 doi:10.4049/jimmunol.171.7.3401
Ishida, D., Yang, H., Masuda, K., Uesugi K., Kawamoto, H., Hattori, M., and Minato, N. Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice. Proc Natl Acad Sci USA. 100(19): 10919-924. 2003 doi:10.1073/pnas.1834525100
Ishida, D., Kometani, K., Yang, H., Kakugawa, K., Masuda, K., Iwai, K., Suzuki, M., Itohara, S., Nakahata, T., Hiai, H., Kawamoto, H., Hattori, M., and Minato, N. Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cells. 4(1): 55-65. 2003 doi:10.1016/s1535-6108(03)00163-6
Kawamoto, H., Ohmura, K., Fujimoto, S., Lu, M., Ikawa, T., and Katsura, Y. Extensive proliferation of T cell lineage committed progenitors in the thymus: an essential process for clonal expression of diverse T cell receptor b chains. Eur J Immunol. 33(3): 606-615. 2003 doi:10.1002/eji.200323461
欧文総説
２０２４
Kawamoto H, Masuda K, Nagano S. Development of Immune Cell Therapy Using T Cells Generated from Pluripotent Stem Cells. Adv Exp Med Biol. 1444:207-217. 2024 doi:10.1007/978-981-99-9781-7_14.
Kawamoto H, Masuda K. Trends in cell medicine: from autologous cells to allogeneic universal-use cells for adoptive T cell therapies. Int Immunol. dxad051. 2024 doi:10.1093/ontimm/dxad051.
２０２３
Nagahata Y, Kawamoto H. Evolutionary reversion in tumorigenesis. Front Oncol. 13:1282417. 2023 doi:10.3389/fonc.2023.1282417.
２０２１
Kawamoto H, Masuda K, Nagano S. Regeneration of antigen-specific T cells by using induced pluripotent stem cell (iPSC) technology. Int Immunol. 33(12):827-833. 2021 doi:10.1093/intimm/dxab091.
Masuda K. and Kawamoto H. Possible NK cell-mediated immune responses against iPSC-derived cells in allogeneic transplantation settings. Inflamm Regen. 41(1):2. 2021 doi:10.1186/s41232-020-00150-7
２０１８
Kawamoto H, Masuda K, Nagano S, Maeda T. Cloning and expansion of antigen-specific T cells using iPS cell technology: development of "off-the-shelf" T cells for the use in allogeneic transfusion settings. Int J Hematol. 107(3):271-277. 2018 doi:10.1007/s12185-018-2399-1
２０１０
Kawamoto H, T Ikawa, K Masuda, H Wada, Y Katsura. A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model. Immunol Rev. 238：23-36: 2010 doi:10.1111/j.1600-065X.2010.00959.x
Kawamoto H, and Wada H, and Katsura Y. A revised scheme for developmental pathways of hematopoietic cells: the myeloid-based model. Int Immunol. 22:65-70. 2010 doi:10.1093/intimm/dxp125.
２００９
Kawamoto H, and Katsura Y. A new paradigm for hematopoietic cell lineages: revision of the claasical concept of the myeloid-lymphoid dichomoty. Trends Immunol. 30(5): 193-200. 2009 doi:10.1016/j.it.2009.03.001.
２００６
Kawamoto H. A close developmental relationship between lymphoid and myeloid lineages. Trends Immunol. 27(4): 169-175. 2006 doi:10.1016/j.it.2006.02.004
２００４
Kawamoto H, and Katsura Y. A new clonal assay system for lymphoid and myeloid lineages. Methods Mol Med. 105: 345-358. 2004 doi:10.1385/1-59259-826-9:345
Kawamoto H, and Minato N. Myeloid cells. Int J Biochem Cell Biol. 36(8):1374-1379. 2004 doi:10.1016/j.biocel.2004.01.020
和文総説
２０２１
長畑洋佑、増田喬子、河本 宏 「血液細胞の起源とミエロイド細胞」臨床血液 62(5), 512-520, (2021) doi:10.11406/rinketsu.62.512
２０１０
河本 宏 「血液細胞の新しい分化経路地図」今日の移植 マクロファージフォーラム 5月号 23(3): 303-308, (2010)
河本 宏 「混合型白血病~起源ステージについての考察~」 血液フロンティア 3月号 20(3): 31-41, (2010)
河本 宏、桂 義元 「白血球分化経路の新しいパラダイム」アレルギー・免疫3月号 17(3): 127-134, (2010)
２００９
河本 宏、桂 義元 「“リンパ球系列”という既成概念からの解放」科学6月号 79(6): 605-614, (2009)
河本 宏、和田はるか 「リンパ系細胞と骨髄系細胞分化の新たな系譜」血液・腫瘍科1月号 58(1): 89-96, (2009)
河本 宏、和田はるか 「T前駆細胞はミエロイド系細胞への分化能を有している」医学のあゆみ 1月号 228(2):185-186, (2009)
２００８
河本 宏、 和田はるか、 桂義元 「血液細胞の新しい分化経路図」 メディカルバイオ 9月号 5(5):78-87, (2008)
和田はるか、 河本 宏、 桂義元 「T前駆細胞はミエロイド系細胞への分化能を保持している」 実験医学 8月号 26:2096-2100, (2008)
河本 宏 「胸腺の発生とT細胞の分化：基本概念の書き換えを迫る新展開」メディカルバイオ 5:22-23, (2008)
河本 宏、桂 義元 「T前駆細胞の発生」メディカルバイオ 5:32-38, (2008)
２００７
佐藤瑠美、 河本 宏 「胸腺における上皮前駆細胞/幹細胞の機能的意義」 Annual Review 免疫2008 177-187, (2007)
２００６
増田喬子、伊川友活、河本 宏「B細胞への分化決定と転写因子」臨床免疫・アレルギー科 46: 547-554, (2006)
角川清和、河本 宏「αβ細胞とγδ細胞の系列分岐要因」臨床免疫・アレルギー科 46:459-464, (2006)
２００５
河本 宏、 増田喬子、 Willem van Ewijk 「胸腺の構築における胸腺細胞と胸腺上皮細胞の相互作用」， Molecular Medicine Vol. 42, 免疫2006, p45-53, (2005)
２００４
伊川友活，Cornelis Murre, 河本 宏．「B細胞系列への決定とE2A」，Molecular Medicine Vol. 41, 免疫2005, 30-38, (2004).
２００３
河本 宏，桂 義元，「樹状細胞サブセットの起源」，現代医療，3, 1763-1770, (2003)
河本 宏，桂 義元，「血液系幹細胞と血液・血管」，再生医学の基礎（名古屋大学出版会），56-90, (2003)
桂 義元，河本 宏，「Tリンパ球の発生分化」，Die Nische3, 5-8, (2003)
河本 宏，桂 義元，「T細胞の発生・分化のゲノム機能」，ゲノム医学，3 (3), 271-280, (2003)
河本 宏，桂 義元，「リンパ球の初期分化」，炎症と免疫，11 (2), 59-68, (2003)