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研究業績

欧文論文

2002

Lu, M., Kawamoto, H., Katsube, Y., Ikawa, T., and Katsura, Y. The common myelolymphoid progenitor: A key intermediate stage in hematopoiesis generating T and B cells. J. Immunol. 169: 3519-3525, 2002.


2001

Kawamoto, H., Katsura, Y. and Amagai, T. Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage.Int. Immunol. 13: 1203-1211, 2001.

Yoshida, Y., Kawamoto, H., Santee, S., M., Hashi, H., Honda, K., Nishikawa, S., Ware, C., F., Katsura and Y., Nishikawa, S.-I. Expression of a4b7 integrin defines a distinct pathway of lymphoid progenitors committed to T cells, fetal intestinal lymphoid producer, NK and dendritic cells. J. Immunol. 167: 2511-2521, 2001.

Egawa, T., Kawabata, K., Kawamoto, H., Amada, K., Okamoto, R., Fujii, N., Kishimoto, T., Katsura, Y. and Nagasawa, T. The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor. Immunity 15: 323-334, 2001

Ikawa, T., Fujimoto, S., Kawamoto, H., Katsura, Y., and Yokota, Y. Commitment to natural killer clels requires the helix-loop-helix inhitibor Id2. Proc.Natl. Acad.Sci.USA 24(9):5164-5169, 2001.

Ohmura, K., Kawamoto, H., Lu, M., Ikawa, T., Ozaki, S., Nakao, K. and Katsura, Y. Immature multipotent hematopoietic progenitors lacking long-term bone marrow-recostituting activity in the aorta-gonad-mesonephros region of murine day 10 fetuses.,J. Immunol. 166:3290-3296, 2001.

Shimizu, C., Kawamoto, H., Yamashita, M., Kimura, M., Kondou, E., Kaneko, Y., Okada, S., Tokuhisa, T., Yokoyama, M., Taniguchi, M., Katsura, Y. and Nakayama, T. Progression of T cell lineage restriciton in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity. Int.Immunol. 13(1):105-117, 2001.


2000

Kawamoto, H., Ikawa, T., Ohmura, K., Fujimoto, S., and Katsura, Y. T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver. Immunity 12, 441-450, 2000.


1999

Kawamoto, H., Fujimoto S., and Katsura, Y. Commitment of common T/NK progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitors assay.J. Exp. Med. 190(11):1617-1625, 1999.

Kawamoto, H., Fujimoto, S., Ozaki, S., Nakao, K. and Katsura, Y. Emergence of T, B and myeloid lineage commitment as well as multipotent hematopoietic progenitors in the AGM region of day 10 fetuses of the mouse.J. Immunol. 163(9):4788-4795, 1999.

Kawabata, K., Ujikawa, M., Egawa, T.,Kawamoto, H., Tachibana, K., Iizawa, H., Katsura, Y., Kishimoto, T., and Nagasawa, T. A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution.Proc.Natl.Acad.Sci. USA 96(10):5663-5667, 1999.

Kawamoto, H., Ohmura, K., Fujimoto S., and Katsura, Y. Emergence of T cell lineage restricted progenitors at the earliest stage of hematopoiesis in the murine fetal liver. J. Immunol. 162(5):2725-2731, 1999.


1998

Kawamoto, H.,Ohmura, K., and Katsura, Y. Presence of progenitors restricted to T, B or myeloid lineage but absence of multipotent stem cells in the murine fetal thymus. J. Immunol. 161(8):3799-3802, 1998.

Nishikawa,S-I., Nishikawa, S.,Kawamoto, H., Yoshida, H., Kizumoto, M., Kataoka, H., Katsura, Y. In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. Immunity 8:761-769, 1998.


1997

Kawamoto, H., Ohmura, K., Katsura, Y. Direct evidence for the commitment of hematopoietic stem cells to T, B and myeloid lineages in murine fetal liver.Int.Immunol. 9(7):1011-1019, 1997.

Kawamoto, H., Ohmura, K., Hattori, N. and Katsura, Y. Hematopoietic progentiors in the murine fetal liver capable of rapidly generating T cells. J.Immunol. 158:3118-3124, 1997.


1996

Kawamoto, H., and Katsura, Y. Isolation of the most immature population of murine fetal thymocytes that includes progenitors capable of generating T, Band myeloid cellsJ.Exp.Med.184:1901-1908, 1996

Hattori,N. Kawamoto, H., Fujimoto, S., Kuno,K., and Katsura, Y. Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus. J.Exp.Med. 184(No.3):1137-1147, 1996.

Wada, K., Kina, T.,Kawamoto, H., Kondo, M. and Katsura, Y.: Requirement of cell interactions through adhesion molecules in the early phase of T cell development.Cell.Immunol. 170:11-19, 1996.


1995

Fujsita, M., Ito, K., Koyama, T., Shino, K., Norioka, M., Kashii, S.,Kawamoto, H.,Monden, S., Kakishita, E., and Okuma, M. Large molecule fraction of plasma separated with polyethylene glycol in treatment of chronic relapsing thrombotic thrombocytopenic purpura. Am J Hematol. 49:149-52. 1995.


1993

Fujita, M., Ito, K., Kawamoto, H., Kashii, S., Norioka, M., Monden, S., and M. Okuma. Characterization of adenosine deaminase (ADA)-negative B-lymphoblastoid cells cocultured with ADA-positive fibroblasts. Eur J Haematol. 50:200-5, 1993.

Kawamoto, H., Ito, K., Kashii, S., Monden, S., Fujita, M., Norioka, M. , Sasai, Y., and Okuma., M. A point mutation in the 5' splice region of intron 7 causes a deletion of exon 7 in adenosine deaminase mRNA. J Cell Biochem. 51:322-5, 1993.


1991

Kashii, S., Ito, K., Monden, S., Sasai, Y., Tsuchida, K., Fujita, M., Kawamoto, H., Norioka, M., Okuma, M. : Adenosine deaminase deficiency due to heterozygous abnormality consisting of a deletion of exon 7 and the absence of enzyme mRNA. J Cell Biochem. 47:49-53, 1991.


欧文総説

2001

Katsura, Y. and Kawamoto, H. Stepwise lineage restriction of progenitors in lympho-myelopoiesis.Intern. Rev. Immunol. 20:1-20, 2001.


2000

Kawamoto, H., Germeraad, W.T.V., and Katsura, Y. Developing thymocytes organize thymic microenvironments. Current Topics in Microbiology and Immunology, 251:125-132, 2000.


1999

Ikawa, T., Kawamoto, H., Fujimoto S., and Katsura, Y. Commitment of common T/NK progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitors assay.J. Exp. Med. 190(11):1617-1625, 1999.


和文総説

2002

河本 宏, 桂 義元:「胎仔胸腺に移行する前駆細胞」,蛋白核酸酵素増刊号 免疫研究の最前線,47 (16), 2159-2165, (2002)

伊川友活, 桂 義元, 河本 宏:「NK細胞系列への決定におけるId2の役割」 臨床免疫, 37(3), 284-290, 2002

河本 宏, 桂 義元:「造血における系列コミットメントのプロセス」臨床血液,, ,43(4), 2002

桂 義元, 河本 宏:「リンパ系細胞の初期分化」別冊医学のあゆみ 免疫疾患,2,4 -8, 2002


2001

河本 宏, 伊川友活, 桂 義元:「胸腺中のT/NK/機上細胞に共通の前駆細胞」免疫2002,, 142-151,

河本 宏, 伊川友活, 桂義元:「前駆細胞はB前駆細胞に比べて胎生の早期に出現する」 臨床免疫,36(4), 584-593, 2001

河本 宏, 桂 義元:「リンパ球亜群への分化と関与要因系列決定は環境によって誘導されるか」臨床血液,36(2),245 -254, 2001

桂 義元, 河本 宏:「造血幹細胞による血液・リンパ球への再生」 炎症と免疫, 9(3),28 -34, 2001

桂 義元, 伊川友活, 河本 宏:「造血幹細胞からリンパ球系列へのコミットメント」実験医学, 19(5), 28-34,2001


2000

河本 宏,  桂 義元:「造血幹細胞からのリンパ球分化」 週刊医学のあゆみ, 194, 1057-1064, 2000

河本 宏,  桂 義元:「樹状細胞サブセットの分化と起源, 細胞工学, 19(9), 1289-1303, 2000

桂 義元,  河本 宏:「造血における系列決定と初期分化の機序」 今日の移植, 13(4), 337-342, 2000

河本 宏, 桂 義元:「T細胞系列を含む造血における分化決定に関する考察」 臨床免疫, 35(1), 65-75, 2000

河本 宏, 桂 義元:「dendritic cellの分化とorigin」 分子呼吸器病, 4(4), 5-10, 2000

桂 義元,  河本 宏:「造血幹細胞/前駆細胞の分化能」 組織培養工学, 26(8), 15-19, 2000

伊川友活,  河本 宏, 桂 義元:「T/NK共通の前駆細胞からT細胞あるいはNK細胞への系列決定」 臨床免疫, 33(3), 282-289,

桂 義元,  河本 宏:「T細胞レパトア形成に必要な2段階の増殖」 組織培養工学, 26(3), 19-23, 2000

河本 宏, 桂 義元:「血液・リンパ系を対象とする再生医療」, 17(2), 42-49, 2000

河本 宏, 桂 義元:「リンパ系前駆細胞」, 応用サイトメトリー(医学書院), 52-56, 2000

河本 宏, 桂 義元:「T細胞分化と関連分子」, 実験医学別冊新用語ライブラリー「免疫」, 48-49, 2000